The Saints lost their first game since the opening day of the season after a second half treble from East end forward Leighton Hopper gave his side the advantage after 70 minutes of stalemate.
With Lee Crammond missing Jay Brown came in to centre half also taking the captains armband, Jack Renwick started in place of Stephen King while Ben McDermott replaced Dale Hood who is sadly out for a long period with a broken leg.
Joe Connor started brightly down the left hand side and twisted and turned past his marker before being denied by smart saves from East End keeper Dan Charlton.
Quay top scorer Alex Foreman was then played through on goal but his powerful strike didn't trouble the keeper and flew over the bar.
East end looked dangerous from set pieces with two big centre halves up for corners and Ethan Dodgson in the Saints goal did well to get up and deflect the ball away when it looked like Whitfield was about to score on the half hour mark.
McDermott who has been in fine form so far this season had a great opportunity to put Willington ahead as he did brilliantly to control a ball that was fired across goal with his right foot before smashing a left footed volley over the bar from 12 yards.
Just before half time East End had their best chance of the half when Hopper found himself one on one with Dodgson but the young keeper produced a quality save at his near post to keep it goalless at the break.
Home keeper Charlton was at his best on the hour mark when Ryan Ferrier let fly with a fantastic long range dipping strike that was heading in before a great strong hand tipped it over the bar.
Charlton was in the action again with 20 minutes to go but this time with an assist as East End took the lead, The keeper launched a goal kick down field that sailed over the Saints backline for Hopper to run onto and with plenty still to do he brilliantly lobbed Dodgson from around 30 yards out to make it 1-0.
Sean Conway almost hit an immediate response for the Quay when he turned onto a pass before firing a powerful low left foot strike that Charlton did brilliantly to get down and keep out with a tremendous save.
The striker then had a massive chance to make it 2 as he raced past the Saints defence before seeing his strike denied by a quality stop from Dodgson who raced out to block with his legs as the striker looked certain to score.
Henda and Pugh sent on Brandon Williams, Harvey Lockwood and new signing Joe Conway for his Saints debut as they looked to get back into the game but it was East end who got the games vital second goal with Hopper this time making no mistake after a long ball was headed on for him to sprint onto and coolly slot home under Dodgson for 2-0.
That goal knocked the stuffing out of the Quay and the home side added a bit of gloss to the score line as the highly impressive Hopper found himself in space in the penalty area once more to smash home a left foot strike into the far corner for his hat trick.
A disappointing end to a game that they had started so well in for the Quay they have the chance to try and get back on track when they face Stobswood away during the xmas holidays (Monday 28th Dec 11am kick off)